Micromegas for the search of solar axions in CAST and low-mass WIMPs in TREX-DM

En este trabajo hemos estudiado la aplicación de los planos de lectura Micromegas, una estructura para la amplificación de la carga en detectores gaseosos, al campo de la detección de sucesos poco probables. En el experimento CAST para la detección de axiones; y en el proyecto TREX-DM para la búsqueda de WIMPs de baja masa. Tanto los axiones como los WIMPs son excelentes candidatos para formar la materia oscura del universo dado que no aparecen como solución ad hoc para resolverlo, sino que se propusieron para solucionar imporantes problemas del Modelo Estandard de física de partículas. Tanto los axiones como los WIMPs producirían un ritmo de sucesos extremadamente bajo y a muy bajas energías. Los detectores Micromegas pueden alcanzar niveles de fondo muy bajas y umbrales de energía por debajo del keV, debido a la granularidad del detector, radiopureza, unifromidad de la respuesta y alta ganancia. Pequeños detectores gaseosos de unos 3 cm de espesor se utilizan en el experimento CAST para la detección de los rayos-x inducidos por los axiones. En este trabajo se muestran los niveles de fondo alcanzados por los detectores del experimento, las técnicas de reducción de fondo y finalmente, en ausencia de una señal positiva, se obtienen límites a la constante de acoplo axion-fotón. Una versión similar, pero superior en tamaño se pretende utilizar para la detección de WIMPs de baja masa en el proyecto TREX-DM. TREX-DM pretende operar un detector a alta presión con un material blanco ligero equipado con planos de lectura Micromegas. Se describe el detector y la puesta a punto del mismo, así como los primeros resultados de la caracterización y la sensibilidad anticipada que puede alcanzar el experimento en caso de operar en un laboratorio subterráneo

Contraste de un modelo de los determinantes de la estancia turística en la era covid-19: implicaciones para la bioseguridad

The reactivation of tourism had been studied by the influence of the habitus of movement and stay, but with the health contingency, this process was mediated by the information from the places with biosecurity protocols. The objective of the present work was to contrast a model of the determinants of stay, considering the mediating variables of the information. A confirmatory, psychometric, and cross-sectional study was carried out with a selection of 100 students from a public university in central Mexico. A factorial structure was found that explained 61% of the variance and established the intention to transfer as a predictor, suggesting the extension of the work towards biosafety protocols.La reactivación del turismo se había estudiado por la influencia del habitus de traslado y estancia, pero con la contingencia sanitaria este proceso estuvo mediatizado por la información de los lugares con protocolos de bioseguridad. El objetivo del presente trabajo fue contrastar un modelo de los determinantes de la estancia, considerando las variables mediadoras de la información. Una confirmación, psicométrico y estudio transversal se llevó a cabo con una selección de 100 estudiantes de una universidad pública en el centro de México. Se encontró una estructura factorial que explicaba el 61% de la varianza y estableció la intención de transferir como predictor, sugiriendo la extensión del trabajo hacia protocolos de bioseguridad.&nbsp

First results of the CAST-RADES haloscope search for axions at 34.67 μeV

We present results of the Relic Axion Dark-Matter Exploratory Setup (RADES), a detector which is part of the CERN Axion Solar Telescope (CAST), searching for axion dark matter in the 34.67μeV mass range. A radio frequency cavity consisting of 5 sub-cavities coupled by inductive irises took physics data inside the CAST dipole magnet for the first time using this filter-like haloscope geometry. An exclusion limit with a 95% credibility level on the axion-photon coupling constant of gaγ & 4 × 10−13 GeV−1 over a mass range of 34.6738μeV < ma < 34.6771μeV is set. This constitutes a significant improvement over the current strongest limit set by CAST at this mass and is at the same time one of the most sensitive direct searches for an axion dark matter candidate above the mass of 25μeV. The results also demonstrate the feasibility of exploring a wider mass range around the value probed by CAST-RADES in this work using similar coherent resonant cavitiesWe wish to thank our colleagues at CERN, in particular Marc Thiebert from the coating lab, as well as the whole team of the CERN Central Cryogenic Laboratory for their support and advice in speci c aspects of the project. We thank Arefe Abghari for her contributions as the project's summer student during 2018. This work has been funded by the Spanish Agencia Estatal de Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) under project FPA-2016-76978-C3-2-P and PID2019-108122GB-C33, and was supported by the CERN Doctoral Studentship programme. The research leading to these results has received funding from the European Research Council and BD, JG and SAC acknowledge support through the European Research Council under grant ERC-2018-StG-802836 (AxScale project). BD also acknowledges fruitful discussions at MIAPP supported by DFG under EXC-2094 { 390783311. IGI acknowledges also support from the European Research Council (ERC) under grant ERC-2017-AdG-788781 (IAXO+ project). JR has been supported by the Ramon y Cajal Fellowship 2012-10597, the grant PGC2018-095328-B-I00(FEDER/Agencia estatal de investigaci on) and FSE-GA2017-2019-E12/7R (Gobierno de Aragón/FEDER) (MINECO/FEDER), the EU through the ITN \Elusives" H2020-MSCA-ITN-2015/674896 and the Deutsche Forschungsgemeinschaft under grant SFB-1258 as a Mercator Fellow. CPG was supported by PROMETEO II/2014/050 of Generalitat Valenciana, FPA2014-57816-P of MINECO and by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements 690575 and 674896. AM is supported by the European Research Council under Grant No. 742104. Part of this work was performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Compilación de Proyectos de Investigacion de 1984-2002

Instituto Politecnico Nacional. UPIICS